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Nolan Cale[1] was a colonist and prospector living at Hadley's Hope on Acheron. He was caught up in the Xenomorph infestation that overran the colony on July 3, 2179.

Cale was one of 38 colonists who fled Hadley's Hope aboard the Onager. They subsequently crash-landed on LV-223, only to discover several Xenomorphs had stowed away aboard the vessel with them.

He became a leader of the survivors, along with Genevieve Dione. He was aware the Xenomorphs got into the cargo bay, but did not tell anyone so he would not be left behind. On October 30, he confessed the truth to everyone.

Later, he and 3 others, attempted to kill the Xenomorphs in the Onager and recover supplies and a transmitter to call for help, only to discover a Hive onboard. The group was killed and he was exposed to a mysterious alien pathogen outside the ship, mutating into a Anathema. Later, on October 31, he lead a attack of Xenomorphs on the survivors hidden camp at night, leading to everyone's death. Except for Derrick Russell, who was in a hidden cave, in a mountain during the attack.

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