The Neonopolis Mafia were an Italian-American criminal gang that was active in Neonopolis in 2030. They were led by Don Giovanni. The Neonopolis Mafia were one of a number of gangs that had acquired stolen Yautja technology from Borgia Industries and was using that technology to wage gang warfare on the streets of Neonopolis. They were on Scarface's third hit list.

After eliminating the mafia, Matadores gang would move in and fill in the vacuum left by the destruction of Neopolis Mafia, though Matadores too would meet the similar fate of their predecessor at the hands of Scarface.

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