- "Comm check. You getting me, Lewis?"
"You're a little fuzzy Marlow, but you're coming through."
- ―Marlow and Lewis (from Alien: Isolation)
Once the Xenomorph outbreak began, Lewis found himself trapped aboard Sevastopol along with the rest of his surviving crew. He was trampled to death in Sevastopol's food court during a mass panic on discovery of an Alien.
When the Anesidora detected the unknown signal coming from LV-426, Lewis got to work attempting to analyze the transmission. After landing on the moon, Lewis stayed aboard the vessel while the rest of the crew set out on foot to try and locate the source of the signal.
After Foster was killed on Sevastopol by the Chestburster she had been impregnated with on LV-426, Lewis, Heyst and Meeks went into hiding on the station. As it was overcome by the Xenomorph infestation they had unwittingly started, Lewis found himself trapped in the Lorenz SysTech Spire as the station's desperate inhabitants attempted to seal themselves away from the creatures. Terrified, surrounded by bodies and hearing a Xenomorph moving through the ventilation ducts in the area, he sent an archive log to Heyst imploring him to come and let him out.
Lewis met his fate in the Sevastopol food court when residents fell into mass panic upon discovering an Alien in the room. He was trampled to death by a crowd of Sevastopol residents fleeing the scene.