In addition to Spliced Xenomorphs created from her own altered DNA, Dr. Fortune also used the DNA of supervillains from Arkham Asylum to create a series of six sentient Spliced Xenomorph hybrids using biomatter from Harvey Dent (Two-Face), The Joker, Pamela Isley (Poison Ivy), Jonathan Crane (Scarecrow), Victor Fries (Mr. Freeze) and Killer Croc (Waylon Jones).
Having added her own DNA in their creation, the first five Xenomorph hybrids also deferred to her and appeared to have a human level of sentience, capable of fluent speech and were also trained in infantry tactics, besting several military personnel from the special forces of various nations.
They were killed when Dr. Fortune tested them against Batman during a fight on an off-shore oil rig with the sixth Xenomorph hybrid created from Killer Croc's DNA being accidentally roused by gunfire and breaking free from its containment.
Dr. Fortune was then killed when the enormous Killer Croc Xenomorph hybrid she had created decapitated her with a headbite after carelessly believing it would not harm her, thinking it would imprint on her and recognise her as its mother as the other Xenomorph hybrids she created had done, strangely ignoring the fact that she had only added her DNA in the development of the first five Xenomorph hybrids she had created and not the Killer Croc Xenomorph hybrid.
All hybrids except for the Poison Ivy Hybrid had Xenomorph-like elongated craniums and; with the exception of the Two-Face hybrid; all of them had dorsal tubes as well, with the Joker hybrid being shown as able to spit acid and the Poison Ivy and Scarecrow hybrids were shown to each have an inner jaw, the Poison Ivy hybrid was also the only hybrid to have a Xenomorph tail.
All five of the sentient supervillain Xenomorph hybrids were shown able to speak English as well as any adult human, with Batman even mentioning to himself that the Two-Face hybrid sounded exactly like Harvey Dent did before he became Two-Face, the Two-Face hybrid was also in command of the team of five hybrids.
The Two-Face hybrid was killed when the ammunition of his firearm exploded from acidic blood sprayed by the Joker hybrid that he had unintentionally fired upon after Batman evaded his gunfire. With those two hybrids dead Dr. Fortune then ordered the Poison Ivy hybrid be in command, the Scarecrow hybrid was then killed as he collided with the christmas tree machinery which released lethal pressure and killed him, the Poison Ivy and Mr. Freeze hybrids were then killed in an explosion.
- Harvey Dent/Two-Face hybrid
- Joker hybrid
- Pamela Isley/Poison Ivy hybrid
- Jonathan Crane/Scarecrow hybrid
- Victor Fries/Mr. Freeze hybrid
- Killer Croc hybrid