Aliens Omnibus: Volume 6 is a trade paperback published by Dark Horse Books on December 31, 2008. It was part of the company's major Omnibus reissue program, which sought to collect and re-release the pre-existing comics from all of Dark Horse's major lines as easily-accessible trade paperbacks. As well as the Aliens comics, similar Omnibus volumes were also released for the Predator and Aliens vs. Predator lines.
Mankind has always struggled to balance exploration and exploitation when stepping into new lands. In the era of the colonization of space, the discovery of new wonders is countered by the awful realities when species once separated by light years of airless void are suddenly thrown together, and the heady intoxication of discovery becomes the feral nightmare of a battle for supremacy. Humanity's arrogance and greed have helped the Alien plague spread, and now men and women must step forward to ensure that the future of the galaxy does not become the age of the Alien!
- The image used on the cover of the omnibus is taken from the 1989 trade paperback release of Aliens: Outbreak, titled Aliens: Book One.
- Headhunters, Border Lines, 45 Seconds, Elder Gods, Tourist Season and Once in a Lifetime are all presented in their original black and white in the Omnibus, thus being the only stories from the Aliens Omnibus series not to be colored since their original publication.